Stomach Acid H2 Blockers H2 antagonists, sometimes referred to as H2RA and also called H2 blockers, are a class of medications that block the action of histamine at the histamine H2 receptors of the parietal cells in the stomach. This decreases the production of stomach acid. Antacids. H2 blockers (histamine blockers) block one of the first stimuli for acid
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